Putterman Lab

Chaim Putterman
Principal Investigator: Chaim Putterman, MD

The Putterman Lab is a leader in the field of immunology and autoimmunity, specifically in its study of systemic lupus erythematosus. Its focus is on the identification and characterization of novel mechanisms, biomarkers and treatment approaches to immune-mediated nephritis, neuropsychiatric lupus, and systemic lupus erythematosus. Of the most notable strengths of the laboratory is its unique position as a cutting-edge basic science hub that is closely-knit with its surrounding large, diverse patient population. This allows for smooth bench-to-bedside, as well as bedside-to-bench transitions that greatly enhance the clinical relevance of the studies, in addition to a better understanding of the pertinent clinical questions that require exploration. It has received funding from the National Institute of Health, Alliance for Lupus Research, Lupus Research Institute, Arthritis Foundation, Boehringer Ingelheim, and Biogen Idec.

Location

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 701N
Bronx, NY 10461

Putterman Lab

Recent Publications:

Stanley S, Vanarsa K, Soliman S, Habazi D, Pedroza C, Gidley G, Zhang T, Mohan S, Der E, Suryawanshi H, Tuschl T, Buyon J, Putterman C, Mok CC, Petri M, Saxena R, Mohan C. Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities. Nature Communications 2020; 4;11(1):2197. doi: 10.1038/s41467-020-15986-3.

Makinde HM, Winter DR, Procissi D, Mike EV, Stock AD, Kando MJ, Gadhvi GT, Droho S, Bloomfield CL, Dominguez ST, Mayr MG, Lavine JA, Putterman C, Cuda CM. A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus. Frontiers Immunology 2020;11:230. doi:10.3389/fimmu.2020.00230.

Stock AD, Der E, Gelb S, Huang M, Weidenheim K, Ben-Zvi A, Putterman C. Tertiary lymphoid structures in the choroid plexus in neuropsychiatric lupus. JCI Insight 2019; 4(11):e124203. doi:10.1172/jci.insight.124203.

Der E, Suryawanshi H, Morozov P, Kustagi M, Goilav B, Ranabothu S, Izmirly P, Clancy R, Belmont HM, Koenigsberg M, Mokrzycki M, Rominieki H, Graham JA, Rocca JP, Bornkamp N, Jordan N, Schulte E, Wu M, Pullman J, Slowikowski K, Raychaudhuri S, Guthridge J, James J, Buyon J, Tuschl T, Putterman C; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium. Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. Nat Immunol. 2019;20(7):915-927.

Chalmers SA, Garcia SJ, Reynolds JA, Herlitz L, Putterman C. NF-kB signaling in myeloid cells mediates the pathogenesis of immune-mediated nephritis. J Autoimmun. 2019; 98:33-43. doi:10.1016/j.jaut.2018.11.004.

Chalmers SA, Glynn E, Garcia SJ, Panzenbeck M, Pelletier J, Dimock J, Seccareccia E, Bosanac T, Khalil S, Harcken C, Webb D, Nabozny G, Fine JS, Souza D, Klein E, Herlitz L, Ramanujam M, Putterman C. BTK inhibition ameliorates kidney disease in spontaneous lupus nephritis. Clin Immunol. 2018; 197:205-218. doi:10.1016/j.clim.2018.10.008.

Mike EV, Makinde HM, Der E, Stock A, Gulinello M, Gadhvi GT, Winter DR, Cuda CM, Putterman C. Neuropsychiatric Systemic Lupus Erythematosus Is Dependent on Sphingosine-1-Phosphate Signaling. Front Immunol. 2018; 9:2189. doi:10.3389/fimmu.2018.02189.

Mike EV, Makinde HM, Gulinello M, Vanarsa K, Herlitz L, Gadhvi G, Winter DR, Mohan C, Hanly JG, Mok CC, Cuda CM, Putterman C. Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus. J Autoimmun. 2019; 96:59-73. doi:10.1016/j.jaut.2018.08.005.

Gelb S, Stock AD, Anzi S, Putterman C, Ben-Zvi A. Mechanisms of neuropsychiatric lupus: The relative roles of the blood-cerebrospinal fluid barrier versus blood-brain barrier. J Autoimmun. 2018; 91:34-44. doi:10.1016/j.jaut.2018.03.001.

Jain S, Stock A, Macian F, Putterman C. A Distinct T Follicular Helper Cell Subset Infiltrates the Brain in Murine Neuropsychiatric Lupus. Front Immunol. 2018; 9:487. doi:10.3389/fimmu.2018.00487

Chalmers SA, Wen J, Doerner J, Stock A, Cuda CM, Makinde HM, Perlman H, Bosanac T, Webb D, Nabozny G, Fine JS, Klein E, Ramanujam M, Putterman C. Highly selective inhibition of Bruton's tyrosine kinase attenuates skin and brain disease in murine lupus. Arthritis Res Ther. 2018; 20(1):10. doi:10.1186/s13075-017-1500-0