Selected Publications

The B7x immune checkpoint pathway: From discovery to clinical trial    

John P, Wei Y, Liu W, Du M, Guan F, Zang X
Trends in Pharmacological Sciences, 40:883-896, 2019
 

Tumor cholesterol up, T cells down    

Picarda E, Ren X, Zang X
Cell Metabolism, 30:12-13, 2019
 

Structures of immune checkpoints: An overview on the CD28-B7 Family    

Liu W, Zang X
Structural Immunology, Springer, 63-78, 2019
 

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality    

Saha A, Taylor PA, Lees CJ, Panoskaltsis-Mortari A, Osborn MJ, Feser CJ, Thangavelu G, Melchinger W, Refaeli Y, Hill GR, Munn DH, Murphy WJ, Serody JS, Maillard I, Kreymborg K, van den Brink M, Dong C, Huang S, Zang X, Allison JP, Zeiser R, Blazar BR.
JCI Insight, 4(19). pii: 127716. doi: 10.1172/jci.insight.127716, 2019
 

Rapid progression of adult T-cell leukemia/lymphoma as tumor infiltrating Tregs after PD-1 blockade    

Rauch DA, Conlon KC, Janakiram M, Brammer JE, Harding JC, Ye BH, Zang X, Ren X, Olson S, Cheng X, Miljkovic MD, Sundaramoorthi H, Joseph A, Skidmore ZL, Griffith O, Griffith M, Waldmann TA, Ratner L.
Blood, 134:1406-1414, 2019
 

Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies   

Wang H, Kaur G, Sankin AI, Chen F, Guan F, Zang X
Journal of Hematology & Oncology, 12:59. doi: 10.1186/s13045-019-0746-1, 2019
 

Human urothelial bladder cancer generates a clonal immune response: The results of T-cell receptor sequencing    

Sankin A, Chand D, Schoenberg M, Zang X.
Urologic Oncology, pii: S1078-1439(19)30144-9. doi: 10.1016/j.urolonc.2019.04.011. [Epub ahead of print]
 

Immune checkpoint B7x(B7-H4/B7S1/VTCN1) is over expressed in spontaneous Canine bladder cancer: The first report and its implications as a preclinical model    

Chand D, Dhawan D, Sankin A, Ren X, Lin J, Schoenberg M, Knapp DW, Zang X.
Bladder Cancer, 5:63-71, 2019
 

PAK kinase inhibition has therapeutic activity in novel preclinical models of Adult T-cell Leukemia/Lymphoma    

Chung EY, Mai Y, Shah UA, Wei Y, Ishida E, Kataoka K, Ren X, Pradhan K, Bartholdy B, Wei X, Zou Y, Zhang J, Ogawa S, Steidl U, Zang X, Verma A, Janakiram M, B. Ye BH
Clinical Cancer Research, 25:3589-3601, 2019
 

Cell-cell contact with proinflammatory macrophages enhances the immunotherapeutic effect by mesenchymal stem cells in two abortion models    

Lin Y, Zhang D, Xu L, Dong L, Lin Y, Huang J, Zhang Y, Tao Y, Zang X, Li DJ, Zheng J, Du M
Cellular and Molecular Immunology, doi: 10.1038/s41423-019-0204-6
 

Blockade of CTLA-4 and Tim-3 pathways induce fetal loss with altered cytokine profiles by decidual CD4+T cells    

Wang S, Chen C, Li M, Qian J, Sun F, Lin Y, Yu M, Wang M, Zang X, Zhu R, Li D, Du M
Cell Death and Disease, 10:15. doi: 10.1038/s41419-018-1251-0, 2019
 

The appropriate frequency and function of decidual Tim-3+CTLA-4+CD8+T cells are important in maintaining normal pregnancy    

Wang S, Sun F, Li M, Qian J, Chen C, Wang MY, Zang X, Li DJ, Yu M, Du M
Cell Death and Disease, 10(6):407. doi: 10.1038/s41419-019-1642-x, 2019
 

2018 Nobel Prize in Medicine awarded to cancer immunotherapy: Immune checkpoint blockade – A personal account    

Zang X
Genes & Diseases, 5:302-303, 2018
 

PD-1/PDL-1 inhibitors as immunotherapy for ovarian cancer (book chapter)    

Moerdler S, Zang X
Ovarian Cancer Immunotherapy, Oxford University Press, 170-192, 2018
 

Wide expression and significance of alternative immune checkpoint molecules, B7x and HHLA2, in PD-L1 negative human lung cancers    

Cheng H, Borczuk A, Janakiram M, Ren X, Lin J, Assal A, Halmos B, Perez-Soler R, Zang X.
Clinical Cancer Research, 24:1954-1964, 2018
 

NF-kB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8+ T cells for tumor promotion    

Li L, Han L, Sun F, Zhou J, Ohaegbulam KC, Tang X, Zang X, Steinbrecher KA, Qu Z, Xiao G.
OncoImmunology, 7:e1435250-13, 2018
 

PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and Foxp3 immune markers    

Ying L, Yan F, Meng Q, Yu L, Yuan X, Gantier MP, Williams BRG, Chan DW, Shi L, Tu Y, Ni P,Wang X, Chen W, Zang X, Xu D, Hu Y.
OncoImmunology, 7:e1433520-11, 2018
 

Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells    

Ohaegbulam KC, Liu W, Jeon H, Almo SC, Zang X.
Oncotarget, 8:82740-82753, 2017
 

An immunoscore using PD-L1, CD68 and tumor–infiltrating lymphocytes (TILs) to predict response to neoadjuvant chemotherapy in invasive breast cancer    

McLemore LE, Janakiram M, Albanese J, Shapiro N, L Y, Zang X. Fineberg S.
Applied Immunohistochemistry & Molecular Morphology, 26:611-619, 2018
 

The expanding repertoire of targets for immune checkpoint inhibition in bladder cancer: what lies beneath the tip of the iceberg, PD-L1    

Sankin A, Narasimhulu D, John P, Gartrell B, Schoenberg M, Zang X.
Urologic Oncology, 36:459-468, 2018
 

The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x and B7-H3    

Janakiram M, Shah UA, Liu W, Zhao A, Schoenberg MP, Zang X.
Immunological Reviews, 276:26-39, 2017
 

A review of the PD-1/PD-L1 checkpoint in bladder cancer: from mediator of immune escape to target for treatment    

Zhou TC, Sankin AI, Porcelli SA, Perlin DS, Schoenberg MP, Zang X.
Urologic Oncology: Seminars and Original Investigations, 35:14-20, 2017
 

HHLA2, a new immune checkpoint member of the B7 family, is widely expressed in human lung cancer and associated with EGFR mutational status    

Cheng H, Janakiram M, Borczuk A, Lin J, Qiu W, Liu H, Chinai JM, Halmos B, Perez-Soler R, Zang X.
Clinical Cancer Research, 23:825-832, 2017
 

HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival    

Koirala P, Roth M, Gill J, Chinai J, Ewart M, Piperdi S, Geller D, Hoang B, Fatakhova K, Ghorpade M, Zang X*, Gorlick R*.
Scientific Reports, 6:31154. doi: 10.1038/srep31154, 2016
 

Molecular pathways: Targeting B7-H3 (CD276) for human cancer immunotherapy    

Picarda E, Ohaegbulam KC, Zang X.
Clinical Cancer Research, 22:3425-3431, 2016
 

Tumor infiltrating lymphocytes as a prognostic and predictive biomarker in breast cancer (book chapter)    

Janakiram M, Khan H, Fineberg S, Zang X, Sparano JA.
Molecular Pathology of Breast Cancer, Springer, 167-186, 2016
 

Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma    

Koirala P, Roth M, Gill J, Piperdi S, Chinai J, Geller D, Hoang B, Park A, Fremed M, Zang X, Gorlick R.
Scientific Reports, 6:30093. doi: 10.1038/srep30093, 2016
 

Immune checkpoint blockade in human cancer therapy: Lung cancer and hematopoietic malignancy    

Janakiram M, Pareek V, Cheng H, Narasimhulu D, Zang X.
Immunotherapy, 8:809-819, 2016
 

Co-stimulate or co-inhibit regulatory T cells, which side to go?    

Liu W, Almo SC, Zang X.
Immunological Investigations, 45:813-831, 2016
 

B7-H4(B7x)-mediated cross-talk between glioma-initiating cells and macrophages via the IL-6/JAK/STAT3 pathway lead to poor prognosis in glioma patients    

Yao Y, Ye H, Qi Z, Mo L, Yue Q, Baral A, Hoon DSB, Vera JC, Heiss JD, Chen CC, Hua W, Zhang J, Jin K, Wang Y, Zang X*, Mao Y*, Zhou L*
Clinical Cancer Research, 22:2778-2790, 2016
 

Emerging targets in cancer immunotherapy: beyond CTLA-4 and PD-1    

Assal A, Kaner J, Pendurti G, Zang X.
Immunotherapy, 7:1169-1186, 2015
 

New immunotherapies targeting the PD-1 pathway    

Chinai JM, Janakiram M, Chen F, Chen W, Kaplan M, Zang X.
Trends in Pharmacological Sciences, 36:587-595, 2015
 

The T-cell inhibitory molecule Butyrophilin-like 2 is up-regulated in mild Plasmodium falciparum infection and is protective during experimental cerebral malaria    

Subramaniam KS, Spaulding E, Ivan E, Mutimura E, Kim R, Liu X, Dong C, Feintuch CM, Zang X, Anastos K, Lauvau G, Daily JP.
The Journal of Infectious Diseases, 212:1322–31, 2015
 

HHLA2 and TMIGD2: New immunotherapeutic targets of the B7 and CD28 families    

Janakiram M, Chinai JM, Zhao A, Sparano JA, Zang X.
OncoImmunology, 4: e1026534-1 - e1026534-3, 2015
 

Substituting threonine187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age    

Zhao H, Bauzon F, Bi E, Yu JJ, Fu H, Lu Z, Cui J, Jeon H, Zang X, Ye BH, Zhu L.
Journal of Biological Chemistry, 290:5797-5809, 2015
 

Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway    

Ohaegbulam KC, Assal A, Lazar-Molnar E, Yao Y, Zang X.
Trends in Molecular Medicine, 21:24-33, 2015
 

B7x/B7-H4 modulates the adaptive immune response and ameliorates renal injury in antibody mediated nephritis    

Pawar RD, Goilav B, Xia Y, Herlitz L, Doerner J, Chalmers S, Ghosh K, Zang X, Putterman C.
Clinical & Experimental Immunology, 179:329-343, 2014
 

Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein    

Janakiram M, Chinai JM, Fineberg S, Fiser A, Montagna C, Medaverepu R, Castano E, Jeon H, Ohaegbulam KC, Zhao R, Zhao A, Almo SC, Sparano JA, Zang X.
Clinical Cancer Research, 21:2359-2366, 2015
 

Structure and cancer immunotherapy of the B7 family member B7x (B7-H4/B7S1)    

Jeon H, Vigdorovich V, Garrett-Thomson SC, Janakiram M, Ramagopal UA, Abadi YM, Lee JS, Scandiuzzi L, Ohaegbulam KC, Chinai JM, Zhao R, Yao Y, Mao Y, Sparano JA, Almo SC, Zang X.
Cell Reports, 9:1089-1098, 2014
* Science-Business eXchange   
 

Tissue-expressed B7-H1 (PD-L1) critically controls intestinal inflammation    

Scandiuzzi L, Ghosh K, Hofmeyer KA, Abadi YM, Lázár-Molnár E, Lin EY, Liu Q, Jeon H, Almo SC, Chen L, Nathenson SG, Zang X.
Cell Reports, 6:625-632, 2014
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The B7 and CD28 families (Book chapter)

Zang X.
Encyclopedia of Medical Immunology, I.R.Mackay and N.R. Rose, ed. Springer, 174-181, 2014
 

HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T cell function    

Zhao R, Chinai JM, Buhl S, Scandiuzzi L, Ray A, Jeon H, Ohaegbulam KC, Ghosh K, Zhao A, Scharff MD, Zang X.
Proceedings of the National Academy of Sciences USA, 110:9879-9884, 2013
 

Curcumin improves the therapeutic efficacy of Listeria-Mage-b vaccine in correlation with improved T cell responses in blood of a triple negative breast cancer model 4T1    

Singh M, Ramos L, Asafu-Adjei D, Quispe-Tintaya W, Chandra D, Jahangir A, Zang X, Aggarwal BB, Gravekamp C
Cancer Medicine, 2:571-582, 2013
 

B7x(B7-H4/B7S1) and myeloid derived suppressor cells in the tumor microenvironment: A tale of two cities    

Jeon H, Ohaegbulam KC, Abadi YM, Zang X.
OncoImmunology, e24744-1-e24744-3, 2013
 

Structure and T cell coinhibition properties of B7 family member B7-H3    

Vigdorovich V, Ramagopal U, Lazar-Molnar E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC.
Structure, 21:707-717, 2013
 

Host B7x promotes pulmonary metastasis of breast cancer    

Abadi YM, Jeon H, Ohaegbulam KC, Scandiuzzi L, Ghosh K, Hofmeyer KA, Lee JS, Ray A, Gravekamp C, Zang X.
The Journal of Immunology, 190:3806-3814, 2013
 

T cell coinhibition and immunotherapy in human breast cancer    

Janakiram M, Abadi YM, Sparano JA, Zang X.
Discovery Medicine, 14:229-236, 2012
 

B7x in the periphery abrogates pancreas specific damage mediated by self-reactive CD8 T cells    

Lee JS, Scandiuzzi L, Ray A, Wei J, Hofmeyer KA, Abadi MY, Loke P, Lin J, Yuan J, Serreze DV, Allison JP, Zang X.
The Journal of Immunology, 189:4165-4174, 2012
 

Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection    

Hofmeyer KA, Scandiuzzi L, Ghosh K, Pirofski LA, Zang X.
The Journal of Immunology, 189:3054-3063, 2012
 

T cell costimulation and coinhibition: Genetics and disease (Review)   

Scandiuzzi L, Ghosh K, Zang X.
Discovery Medicine, 12:119-128, 2011
 

The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion (Review)   

Hofmeyer KA, Jeon H, Zang X.
Journal of Biomedicine and Biotechnology, 2011:451694, 2011
 

Tissue specific expression of B7x protects from CD4 T cell mediated autoimmunity   

Wei J, Loke P, Zang X*, Allison JP*.
(* Co-corresponding authors)
Journal of Experimental Medicine, 208:1683-1694, 2011
 

T cell coinhibition in prostate cancer: new immune evasion pathways and emerging therapeutics (Review)   

Barach YS, Lee JS, Zang X.
Trends in Molecular Medicine, 17:47-55, 2011
 

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas   

Zang X, Sullivan PS, Soslow RA, Waitz R, Reuter VE, Wilton A, Thaler HT, Arul M, Slovin SF, Wei J, Spriggs DR, Dupont J, Allison JP.
Modern Pathology, 23:1104-1112, 2010
 

Mouse Mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis.   

Scandiuzzi L, Beghdadi W, Daugas E, Abrink M, Tiwari N, Brochetta C, Claver J, Arouche N, Zang X, Pretolani M, Monteiro RC, Pejler G, Blank U.
The Journal of Immunology, 185:624-633, 2010
 

The contrasting role of B7-H3 (Commentary)   

Hofmeyer KA, Ray A, Zang X.
Proceedings of the National Academy of Sciences USA, 105: 10277-10278, 2008
 

Serum soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage   

Thompson RH*, Zang X*, Lohse CM, Leibovich BC, Slovin S, Reuter VE, Blute ML, Russo P, Kwon ED*, Allison JP*.
(*Contributed equally)
Cancer Research, 68: 6054-6058, 2008
 

The B7 family and cancer therapy: Costimulation and coinhibition (Review)   

Zang X, Allison JP.
Clinical Cancer Research, 13: 5271-5279, 2007
 

B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome   

Zang X*, Thompson RH*, Al-Ahamadie A, Serio AM, Reuter VE, Eastham JA, Scardino PT, Sharma P, Allison JP.
(*Contributed equally)
Proceedings of the National Academy of Sciences USA, 104: 19458-19463, 2007
 

T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface   

Cao E*, Zang X*, Ramagopal UA*, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, DiLorenzo TP, Allison JP, Nathenson SG, Almo SC.
(*Contributed equally)
Immunity, 26: 311-321, 2007
 

Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic Infection    

Loke P, Gallagher I, Nair MG, Zang X, Brombacher F, Mohrs M, Allison JP, Allen JE.
Journal of Immunology, 179: 3926-3936, 2007
 

To be or not to be B7 (Commentary)   

Zang X, Allison JP.
Journal of Clinical Investigation, 116: 2590-2593, 2006
 

A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors   

Zang X, Loke P, Kim J, Wojnoonski K, Kusdra L, Allison JP.
Genomics, 88: 841-845, 2006
 

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection    

Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen IE, Allison JP.
Proceedings of the National Academy of Sciences USA, 102: 9872-9877, 2005
 

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1   

Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM.
Nature Immunology, 4:670-679, 2003
 

B7x: A widely expressed B7 family member that inhibits T cell activation   

Zang X, Loke P, Kim J, Murphy K, Waitz R, Allison JP.
Proceedings of the National Academy of Sciences USA, 100: 10388-10392, 2003
 

Cloning and characterisation of mmc-1, a microfilarial-specific gene, from Brugia pahangi   

Emes R, Thompson F, Moore J, Zang X, Devaney E.
International Journal for Parasitology, 32:415-424, 2002
 

Homologues of human macrophage migration inhibitory factor from a parasitic nematode: Gene cloning, protein activity, and crystal structure   

Zang X, Taylor P, Wang JM, Meyer DJ, Scott AL, Walkinshaw MD, Maizels RM.
Journal of Biological Chemistry, 277:44261-44267, 2002
 

A Brugia malayi homolog of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection   

Falcone FH, Loke P, Zang X, MacDonald AS, Maizels RM, Allen JE.
Journal of Immunology, 167: 5348-5354, 2001
 

Immune evasion genes from filarial nematodes (Review)    

Maizels RM, Gomez-Escobar N, Gregory WF, Murray J, Zang X.
International Journal for Parasitology, 31:889-898, 2001
 

Serine proteinase inhibitors from nematodes and the arms race between host and pathogen (Review)   

Zang X, Maizels RM.
Trends in Biochemical Sciences, 26:191-197, 2001
 

The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong but short-lived immune responses in mice and humans    

Zang X, Atmadia KA, Gray P, Allen JE, Gray CA, Lawrence RA, Yazdanbakhsh M, Maizels RM.
Journal of Immunology, 165:5161-5169, 2000
 

Vaccination against helminth parasites: the ultimate challenge for vaccinologists? (Review)   

Maizels RM, Holland M, Falcone F, Zang X, Yazdanbakhsh M.
Immunological Reviews, 171:125-147, 1999
 

A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases   

Zang X, Yazdanbakhsh M, Jiang HB, Kanost MR, Maizels RM.
Blood, 94:1418-1428, 1999