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Stephanie Rudolph, Ph.D.

Stephanie Rudolph, Ph.D.

Assistant Professor, Dominick P. Purpura Department of Neuroscience

Assistant Professor, Department of Psychiatry and Behavioral Sciences

Area of Research: Our research focuses on how neuromodulation affects synaptic plasticity, inhibition, and multisensory integration to shape behavior in health and disease.

Contact Information

718.430.3120718.430.8821stephanie.rudolph@einsteinmed.org

Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South, Room 116
Bronx, NY 10461

Research Profiles

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Professional Interests

We see a friend and wave hello, we hear a bird’s song and lift our head towards the tree branch, we smell a fresh pastry and rush into the bakery. As we navigate the world, we are confronted with a wealth of sensory information that we constantly have to detect, integrate, and filter to generate an appropriate behavioral response. How we respond requires the interplay of numerous brain regions, and depends on many factors, including the context in which a sensory stimulus occurred, previous experience, and internal state. The cellular and molecular correlates for these external and internal factors are e.g. the release of context-dependent neuromodulators, altered neuronal activity, synaptic plasticity, and gene expression. On a circuit level, these mechanisms regulate local integration of information on varying time scales, and ultimately control output to other brain regions. We aim to identify the molecular, cellular, and circuit mechanisms that allow the cerebellum, an area of the brain that receives rich multisensory input, to dynamically respond to physiological context. We focus on the neuromodulatory systems involved in autonomic and metabolic regulation, social interactions, and sex-specific signaling. Using genetic and viral approaches, electrophysiology, and behavioral testing we examine the anatomical and molecular basis of neuromodulation in the mouse cerebellum, identify the circuit elements that respond to modulatory signals, and elucidate how this alters cerebellar output. Our ultimate goal is to better understand how context-dependent modulation of cerebellar function controls motor behavior, cognition, and emotion in health and disease.

Selected Publications

1. Rudolph S, Guo C, Pashkovski S, Osorno T, Gillis W, Krauss JM, Nyitrai H, Flaquer I, El-Rifai M, Datta RS, Regehr WG, Cerebellum-specific deletion of the GABA_A receptor d subunit alters anxiety-like, social and maternal behaviors without affecting motor performance BioRxiv, https://doi.org/10.1101/2019.12.27.889014

2. A transcriptomic atlas of the mouse cerebellum reveals regional specializations and novel cell types

Kozareva V, Martin C, Osorno T, Rudolph S, Guo C, Vanderburg C, Nadaf N, Regev A, Regehr WG, Macosko E BioRxiv, https://doi.org/10.1101/2020.03.04.976407

3. Tsai PT, Rudolph S, Guo C, Ellegood J, Gibson JM, Schaeffer SM, Mogavero J, Lerch JP, Regehr WG, Sahin M. Sensitive Periods for Cerebellar Mediated Autistic-like Behaviors. Cell Reports. 2018; 25(2), 357-367.e4

4. Pieper A*, Rudolph S*, Wieser GL, Götze T, Mießner H, Yonemasu T, Yan K, Tzvetanova I, Duverge Castillo B, Bode U, Bormuth I, Wadiche JI, Schwab MH, Goebbels S. Sci Rep. 2019 Feb 5;9(1):1448 NeuroD2 controls inhibitory circuitry formation in the molecular layer of the cerebellum. *equal contribution

5. Tang JC, Rudolph S, Cepko CL. Viral Delivery of GFP-Dependent Recombinases to the Mouse Brain. Methods Mol Biol. 2017; 1642:109-126. PMID: 28815497

6. Tang JC, Drokhlyansky E, Etemad B, Rudolph S, Guo B, Wang S, Ellis EG, Li JZ, Cepko CL. Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. Elife. 2016 May 20;5. pii: e15312.

7. Witter L*, Rudolph S*, Pressler RT, Lahlaf SI, Regehr WG. 2016 Jul 20;91(2):312-9. Purkinje Cell Collaterals Enable Output Signals from the Cerebellar Cortex to Feed Back to Purkinje Cells and Interneurons. Neuron *equal contribution

8. Guo C, Witter L, Rudolph S, Elliott HL, Ennis KA, Regehr WG. Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex. Neuron. 2016 Sep 21;91(6):1330-41.

9. Rudolph S, Hull C, Regehr WG. Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells. J Neurosci. 2015, 35(47):15492-504.

10. Tang JC, Rudolph S, Dhande OS, Abraira VE, Choi S, Lapan SW, Drew IR, Drokhlyansky E, Huberman AD, Regehr WG, Cepko CL. Cell type-specific manipulation with GFP-dependent Cre recombinase. Nat Neurosci. 2015, 18(9):1334-41.

11. Coddington LT, Rudolph S, Vande Lune P, Overstreet-Wadiche L, Wadiche JI, Spillover Activation of Inhibition Segregates Interneuronal Subpopulations in the Cerebellar Cortex. Neuron 2013, 78(6):1050-62.

12. Leuner K, Li W, Amaral MD, Rudolph S, Calfa G, Schuwald AM, Harteneck C, Inoue T, Pozzo-Miller L. Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels. Hippocampus 2012, 23(1):40-52

13. Rudolph S, Overstreet-Wadiche L, Wadiche JI, Desynchronization of multivesicular release enhances Purkinje cell output. Neuron. 2011, 70(5):991-1004

14. Nadrigny F, Li D, Kemnitz K, Ropert N, Koulakoff A, Rudolph S, Vitali M, Giaume C, Kirchhoff F, Oheim M. Systematic colocalization errors between acridine orange and EGFP in astrocyte vesicular organelles. Biophysical journal. 2007; 93(3):969-80.

Reviews:

1. Rudolph S, Tsai MC, von Gersdorff H, Wadiche JI. The ubiquitous nature of multivesicular release. TINS 2015, Jul;38(7): 428-38,

2. Rudolph S., Thanawala M. Location matters: Somatic and dendritic SK channels answer to distinct calcium signals. JNeurophys, 2015, 2015 Jul;114(1):1-5

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Stephanie Rudolph, Ph.D.

Contact Information

Professional Interests

Selected Publications