Weblink: http://www.researchgate.net/profile/Gaetano_Santulli
Hirsch Index: 48 (i10 index: 90)
Role of endothelial GRK2 in angioedema.
Hypertension. 2020, in press.
Metabolic flexibility of mitochondria plays a key role in balancing glucose and fatty acid metabolism in the diabetic heart.
Diabetes. 2020, in press.
Is COVID-19 an endothelial disease? A comprehensive evaluation of clinical and basic evidence.
Journal of Clinical Medicine. 2020, in press.
A small molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy.
Nature Cancer. 2020;1(3):315-328.
Cardiomyocyte-derived exosomal microRNA-92a mediates post-ischemic myofibroblast activation both in vitro and ex vivo.
European Society of Cardiology – Heart Failure (ESC-HF). 2020; in press.
In type 2 diabetes, intensive glucose control for 5.6 years did not differ from usual care for major CV events at 14 years.
Annals of Internal Medicine. 2019;171(6):JC31.
Exosomal microRNA: The revolutionary endogenous Innerspace nanotechnology.
Science Translational Medicine. 2018;10(467):eaav9141.
Ryanodine Receptor calcium leak in circulating B-lymphocytes as a biomarker in heart failure.
Circulation. 2018;138:1144-1154. F1000 recommended article.
Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells.
Sci. Reports. 2017;7:15823.
Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.
Cell Commun. 2017;15(1):47.
Effects of alpha-lipoic acid on multiple cytokines and biomarkers and recurrence of atrial fibrillation within one year of catheter ablation.
Am J Cardiol. 2017;119:1382-1386.
Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS.
PNAS. 2016;113:8532-8537.
Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation.
PNAS. 2016;113(32):9069-74.
Mitochondrial calcium overload is a key determinant in heart failure.
PNAS. 2015;112:11389-94 (with Editorial Commentary); F1000 recommended article.
Highly cited article (Thomson Reuters: Top 1% in Biomedicine)
Mitochondrial oxidative stress promotes atrial fibrillation.
Sci Reports. 2015;5:11427.
Beta-blockers in diabetic patients with heart failure.
JAMA Intern Med. 2015;175(4):657.
Calcium release channel RyR2 regulates insulin release and glucose homeostasis.
Journal of Clinical Investigation. 2015;125:1968-1978.
Highly cited article (Thomson Reuters: Top 1% in Biomedicine)
A selective microRNA-based strategy inhibitS restenosis while preserving endothelial function.
Journal of Clinical Investigation. 2014;124:4102-4114 (with Editorial Commentary).
Highly cited article (Thomson Reuters: Top 1% in Biomedicine)
Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging.
PNAS. 2014;111:15250-5.
CaMK4 gene deletion induces hypertension.
JAHA. 2012;1:e001081.
Coronary heart disease risk factors and mortality.
JAMA. 2012; 307:1137.
Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo.
Hypertension. 2012;60:129-136.
Age-related impairment in insulin release: the essential role of Beta2 Adrenergic Receptor.
Diabetes. 2012;61:692-701.
Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.
Cell Signal. 2012;24:468-475.
G protein-coupled receptor kinase 2 in patients with acute myocardial infarction.
Am J Cardiol. 2011;107:1125-1130.
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Molecular Cell. 2011;42:84-95.
The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα.
PNAS. 2008;195:17818-17823.
Ischemic neoangiogenesis enhanced by β2-adrenergic receptor overexpression - A novel role for the endothelial adrenergic system
Circulation Research. 2005; 97:1182-1189.
AKT Participates in Endothelial Dysfunction in Hypertension.
Circulation. 2004; 109:2587-2593.
Full list of peer-reviewed papers
-Books:
-Cardiovascular Disease and Diabetes: A Journey from Bench to Bedside. eds. Frontiers. Editor: Gaetano Santulli (2019)
-MITOCHONDRIAL DYNAMICS IN CARDIOVASCULAR MEDICINE. Hardcover Book (646 pages) – eds. Springer-Nature. Editor: Gaetano Santulli (2017)
-DIET AND METABOLIC DYSFUNCTON. Hardcover Book – eds. MDPI, Basel, Switzerland. Adapted from the Special Issue published in Nutrients. Editor: Gaetano Santulli. (2017)
-microRNA: FROM MOLECULAR BIOLOGY TO CLINICAL PRACTICE. Hardcover Book – 3 volumes, eds. Springer Editor: Gaetano Santulli (2016)
-ADRENAL GLANDS: FROM PATHOPHYSIOLOGY TO CLINICAL PRACTICE. Hardcover Book, eds. Nova Publishers Inc. Editor: Gaetano Santulli (2015)
-ANGIOGENESIS: INSIGHTS FROM A SYSTEMATIC OVERVIEW. Hardcover Book, eds. Nova Publishers Inc. Editor: Gaetano Santulli (2013).
-Book chapters:
-Gaetano Santulli, Daniel Lewis, Andrew Marks, and Joachim Frank. Ryanodine receptor structure and function in health and disease. In “Membrane-bound Macromolecular Protein Complexes: Structure and Function”. Editors: Dr. J. Robin Harris and E. Boekema. eds. Springer-Nature (2018).
-Daniela Sorriento, Gaetano Santulli, et al. The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium/Calmodulin Dependent Transcription Factors. In “Calcium Signaling in Human Health and Diseases”. Editor: F. Moccia, eds. MDPI (2018).
-Jessica Gambardella, Bruno Trimarco, Guido Iaccarino, and Gaetano Santulli (Corresponding Author). New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling. In “Heart Failure: From Research to Clinical Practice”. Editor: Shaidul Islam (Karolinska Institutet), eds. Springer-Nature (2017).
-M. Ciccarelli, D. Sorriento, E. Coscioni, G. Iaccarino, G. Santulli (Corresponding Author). Adrenergic Receptors. In “Endocrinology of the heart in health and disease”. Editors: JC. Schisler, CH. Lang, MS. Willis, eds. Elsevier (2016).
-G. Santulli (Corresponding Author) et al. Essential roles of intracellular calcium release channels in muscle, brain and metabolism. In “50th Anniversary of Calcium Channel Research: Biomedical Perspectives”. eds. Bentham Science, Potomac, MD, USA (2015).
-Gaetano Santulli. The adrenergic system in cardiovascular metabolism and aging. In “The cardiovascular adrenergic system”. Hardcover Book, Editor: A. Lymperopoulos, eds. Springer (2018).
-Gaetano Santulli. Sympathetic Nervous System Signaling in Heart Failure and Cardiac Aging. In “Pathophysiology and Pharmacotherapy of Cardiovascular Disease”. Editor: G. Jagadeesh, eds. Springer (2015).