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  • Mariana Figuera-Losada, Ph.D.

Mariana Figuera-Losada, Ph.D.

Mariana Figuera-Losada

Instructor, The Saul R. Korey Department of Neurology

Contact Information

718.920.2880718.798.4532

Montefiore Medical Center
3411 Wayne Avenue
Bronx, NY 10467

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Professional Interests

I am interested in the understanding of the molecular basis of human brain diseases and the discovery of novel therapies and treatments. I focus my efforts in clinical research for sleep-wake disorders including narcolepsy, idiopathic hypersomnia and sleep apnea.


Selected Publications

  • Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. Figuera-Losada M, Stathis M, Dorskind JM, Thomas AG, Bandaru VV, Yoo SW, Westwood NJ, Rogers GW, McArthur JC, Haughey NJ, Slusher BS, Rojas C. PLoS One. 2015 May 26;10(5):e0124481. doi: 10.1371/journal.pone.0124481. eCollection 2015.
  • Inhibition of microglia activation as a phenotypic assay in early drug discovery. Figuera-Losada M, Rojas C, Slusher BS. J Biomol Screen. 2014 Jan;19(1):17-31. doi: 10.1177/1087057113499406. Epub 2013 Aug 14. Review.
  • A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases. Feng Y, Chambers JW, Iqbal S, Koenig M, Park H, Cherry L, Hernandez P, Figuera-Losada M, LoGrasso PV. ACS Chem Biol. 2013 Aug 16;8(8):1747-54. doi: 10.1021/cb3006165. Epub 2013 Jun 10.
  • Targeting the glutamatergic system for the treatment of HIV-associated neurocognitive disorders. Potter MC, Figuera-Losada M, Rojas C, Slusher BS. J Neuroimmune Pharmacol. 2013 Jun;8(3):594-607. doi: 10.1007/s11481-013-9442-z. Epub 2013 Apr 4. Review.
  • Structural mechanisms of allostery and autoinhibition in JNK family kinases. Laughlin JD, Nwachukwu JC, Figuera-Losada M, Cherry L, Nettles KW, LoGrasso PV. Structure. 2012 Dec 5;20(12):2174-84. doi: 10.1016/j.str.2012.09.021. Epub 2012 Nov 8.
  • Enzyme kinetics and interaction studies for human JNK1β1 and substrates activating transcription factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun). Figuera-Losada M, LoGrasso PV. J Biol Chem. 2012 Apr 13;287(16):13291-302. doi: 10.1074/jbc.M111.323766. Epub 2012 Feb 17.
  • Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase interacting motif-1 (KIM1). Chambers JW, Cherry L, Laughlin JD, Figuera-Losada M, Lograsso PV. ACS Chem Biol. 2011 Aug 19;6(8):808-18. doi: 10.1021/cb200062a. Epub 2011 May 24. 
  • Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM). Figuera-Losada M, Ranson M, Sanderson-Smith ML, Walker MJ, Castellino FJ, Prorok M. Biochim Biophys Acta. 2010 Jun;1804(6):1342-9. doi: 10.1016/j.bbapap.2010.01.019. Epub 2010 Feb 10.
  • Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors. Kamenecka T, Jiang R, Song X, Duckett D, Chen W, Ling YY, Habel J, Laughlin JD, Chambers J,Figuera-Losada M, Cameron MD, Lin L, Ruiz CH, LoGrasso PV. J Med Chem. 2010 Jan 14;53(1):419-31. doi: 10.1021/jm901351f. Erratum in: J Med Chem. 2010 Feb 25;53(4):1882.
  • The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain. Fu Q, Figuera-Losada M, Ploplis VA, Cnudde S, Geiger JH, Prorok M, Castellino FJ. J Biol Chem. 2008 Jan 18;283(3):1580-7. Epub 2007 Nov 26.
  • Rapid selection of Drosophila S2 cells with the puromycin resistance gene. Iwaki T, Figuera M, Ploplis VA, Castellino FJ. Biotechniques. 2003 Sep;35(3):482-4, 486.
  • Structure-function analysis of the streptokinase amino terminus (residues 1-59). Mundada LV, Prorok M, DeFord ME, Figuera M, Castellino FJ, Fay WP. J Biol Chem. 2003 Jul 4;278(27):24421-7. Epub 2003 Apr 18.
  •  Interaction of Leishmania mexicana promastigotes with the plasminogen-plasmin system. Avilan L, Calcagno M, Figuera M, Lemus L, Puig J, Rodriguez AM. Mol Biochem Parasitol. 2000 Oct;110(2):183-93.
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