Research in the department of cell biology focuses on understanding molecular mechanisms of gene regulation in eukaryotic cells. Our goal is to comprehend the normal regulatory mechanisms and how they are disrupted in diseases, especially cancer. Using mammalian cells, yeast, viruses, fruit flies and transgenic mice, we are investigating mechanisms of DNA replication and repair, control of the cell cycle and apoptosis, roles for transcriptional regulation and chromatin structure in gene expression, RNA processing, intracellular trafficking, membrane fusion and budding, mechanisms of generating antibody diversity, and the functions of cell surface sugars.
What's Hot: A department researcher found that antibiotics may prevent sickle cell crisis and could offer the first strategy for warding off long-term complications such as organ failure.
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