Areas of Research: Central regulation of metabolism; metabolic and endocrine aspects of aging; neuroendocrine regulation of aging.
Areas of Research: We study the genetic of longevity, hypothesizing that centenarians have protective genes that allows the delay of aging and protect against age-related diseases.
Areas of Research: Hypothalamic regulation of energy balance and feeding; Melanocortin regulation of fertility and reproduction; FGF signaling and glucose control; Leptin and leptin receptor models of obesity and diabetes;
Areas of Research: autoimmune diseases and autoantigens; immunopathogenesis of type 1 diabetes; humanized disease models; immunomodulatory therapies
Professor, Department of Medicine (Endocrinology)
Harold and Muriel Block Chair in Medicine
Director, Global Diabetes Institute
Areas of Research: Central regulation of glucose metabolism (humans and rodents)
Adipose tissue inflammation
Malnutrition-Modulated Diabetes Mellitus
Hypoglycemia-Associated Autonomic Failure
Areas of Research: My lab is focused on the biology of aging, with a particular interest on metabolism, IGF-1 signaling, and the role of cell autonomous and non-cell autonomous mediators of aging phenotypes utilizing heterochronic parabiosis.
Areas of Research: Neurobiology of obesity, Electrophysiological analysis of hypothalamic neurons, Neuronal mapping of feeding-related circuits, Behavioral evaluation of cell type-specific circuit connections using optogenetics
Areas of Research: Immunotherapies; Autoimmunity and autoantigens; Humanized mice models; Antigen presentation; Proinflammatory cytokines; Beta cell dysfunction; Pathophysiology of type 1 and type 2 diabetes; Thyroid autoimmunity; Endoplasmic Reticulum stress
Areas of Research: Regulation of glucose metabolism
Epigenetic modifications regulating metabolism
Regulation of lipogenic gene transcription and de novo lipogenesis
adipocyte and liver biology
Integrative metabolic signaling
Areas of Research: Obesity/ diabetes, gut-brain neuroendocrine communication in the control of feeding and energy balance, neuronal nutrient sensing, neural control of thermogenesis, lipolysis and gastrointestinal function.
Areas of Research: My lab is focused on the biology of adipocytes. Understanding basic biology of adipocytes is fundamental to the treatment and prevention of type 2 diabetes/obesity.
Areas of Research: We are interested in studying the roles of autophagy in metabolic regulation in physiology, during obesity, and with age.
Areas of Research: prevention and treatment of osteoporosis, thyroid cancer, endocrine disorders in the elderly
Areas of Research: 1. Immunogenetics of autoimmune Thyroid disease (AITD) and type 1 diabetes (T1D)
2.Gene-environment interactions in AITD and T1D
3. Epigenetics of AITD and T1D
4. Environmental chemical triggers of T1D
Areas of Research: Role of diet and other lifestyle variables in the development of chronic diseases, prevention, and control of obesity-related cardiometabolic diseases, diabetes,
Areas of Research: Regulation of gene transcription, lipid and glucose metabolism, hepatocyte and adipocyte biology, metabolic diseases
Areas of Research: Central and peripheral glial and neuronal processes that control systemic and adipose tissue lipid metabolism, and affective behaviors as well.
Key words: Adipose tissue; Affective behaviors; Astrocyte; Diabetes; Neural circuit; Obesity.