Gruss Magnetic Resonance Research Center

Craig Branch, Ph.D.


Gruss Magnetic Resonance Research Center
Associate Professor
Departments of Radiology, Physiology Biophysics

Office: 208 Gruss MRRC
Phone: (718) 430-3390 


Education and Certifications 

B.S (Mathematics), M.S. (Applied Mathematics), Ph.D. (Biophysics)


Expertise and Research Interests 

My research focuses on the development and application of Magnetic Resonance Imaging (MRI) methods for the assessment of brain function, with a emphasis upon the application of MRI methodology to translational research. My principal interests reside in measures of brain function, quantitative MR relaxation mechanisms and development of novel contrast and tagging methods. Functional Imaging methods of interest include Blood Oxygenation Level Dependent (BOLD) contrast imaging, quantitative cerebral perfusion imaging, quantitative diffusion imaging and phosphorous and proton metabolite chemical shift imaging. Principal areas of interest include mild brain trauma (experimental and clinical), schizophrenia, Alzheimer’s disease and related brain disorders.

As director of the Gruss MRRC, I engage in collaborative activities designed to further new and novel applications by Einstein staff.  I am available for consultation, direct support of student research and novel technique implementation for facility users.

Specific focus areas:

  • Multicompartment T2 imaging of myelination: calibration using mouse models of myelin and microtuble deficits.
  • Correlation of diffusion tensor imaging with multicompartment relaxaion in white matter.
  • Structural imaging of microstructural white matter abnormalities in experimental head trauma.
  • Spatial Specificity of functional Imaging measure. 
  • Anatomical and Relaxographic Imaging of Mouse Models of Psychiatric Disease.
  • Fluorinated analogs of LDOPA and 5HTP for MRI measurement of receptor funtion.


Selected Publications 

Portnoy HD, Chopp M, Branch CA: Hydraulic Model of Myogenic Autoregulation and the Cerebrovascular Bed: The Effects of Altering Systemic Arterial Pressure.  Neurosurg, 13:482-498, 1983.

Ewing JR, Branch CA, Helpern JA, Cerebral Blood Flow Measured by NMR Indicator Dilution in Cats.  Stroke, 20(2): 259-267, 1989.

Branch CA, Helpern JA, Ewing JR, Welch KMA: 19-F NMR Imaging of Cerebral Blood Flow. Mag Reson Med, 20(1):151-157, 1991.

Branch CA, Ewing JR, Helpern JA, Ordidge RJ, Butt S, Welch KMA: Atraumatic Quantitation of Cerebral Perfusion in Cats by 19-F Magnetic Resonance Imaging, Mag Res Med, 28:39-53, 1992.

Branch CA, Hernandez L, Yongbi M, Helpern JA: Rapid and Continuous Monitoring Cerebral Perfusion by Magnetic Resonance Line Scan Assessment with Arterial Spin Tagging.   NMR in Biomed.  11:1-11, 1998.

Hernandez L, Branch CA: Flow Velocity and MTC on the Efficiency of Adiabatic Fast Passage Inversion:  Practical Consideration for Quantitive CBF Imaging. Proc 5th ISMRM (In Review, NMR Biomedicine, Dec 1998),  3:1753, 1997.

Yongbi MN, Branch CB, Helpern JA:  Perfusion Imaging Using FOCI RF Pulses, Magn Reson Med., 40(6):938-43, 1998.

Lipton ML, Branch CA, Hrabe J, Lewis DP, Helpern JA.RF excitation profiles with FAIR: impact of truncation of the arterial input function on quantitative perfusion. J Magn Reson Imaging. 2001 Feb;13(2):207-14.

Pell GS, Lewis DP, Branch CA.:  Pulsed arterial spin labeling using TurboFLASH with suppression of intravascular signal.  Magn Reson Med  2003 Feb;49(2):341-50.

Pell GS, Lewis DP, Ordidge RJ, Branch CA, “TurboFLASH FAIR Imaging with optimized inversion and imaging profiles.” Magn Reson Med. 2004 Jan;51(1):46-54.

Dingman S, Hurlburt L, Branch C. Acute no-effect dose for in ova exposure to C3F7 tagged 5-hydroxytryptophan, a novel probe for investigating neural development. Mol Imaging Biol.  Feb; 6(1):12-6.  2004 Jan.

Dingman S, Mack D, Branch S, Thomas R, Guo C, Branch C. The fate of perfluoro-tagged metabolites of L-DOPA in mice brains.J Immunoassay Immunochem. 2004;25(4):359-70.

Delisi LE, Bertish H, Brown K, Li C, Ardekani B, Branch CA:  Early detection and longitudinal follow-up of schizophrenia using MRI. Schizophrenia Bulletin, 33, 365-366, 2007.

Chen Y, Dyakin V, Branch CA, Ardekani B, Yang D, Guilfoyle DN, Peterson J, Peterhoff C, Ginsberg SD, Cataldo AM, Nixon RA:  In Vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model. Neurobiology of Aging, Manuscript Number: NBA-07-251R2, Aging. Epub Ahead of Print: 2008 Jan 2.

Hernandez-Garcia L, Lewis DP, Moffat B, Branch CA. Magnetization transfer effects on the efficiency of flow-driven adiabatic fast passage inversion of arterial blood. NMR Biomed. 2007 Dec;20(8):733-42.

Li X, Branch CA, Bertisch HC, Brown K, Szulc KU, Ardekani BA, DeLisi LE: An fMRI Study of Language Processing in People at High Genetic Risk for Schizophrenia.  Schizophrenia Research, 2007, 91: 62-72.

Lipton ML, Gellella E, Lo C, Gold T, Ardekani BA, Shifteh K, Bello JA, Branch CA. Multifocal white matter ultrastructural abnormalities in mild traumatic brain injury with cognitive disability: a voxel-wise analysis of diffusion tensor imaging, J Neurotrauma. 2008 Nov;25(11):1335-42.

Dingman S, Mack D, Branch S, Thomas R, Guo C, Branch C. The fate of perfluoro-tagged metabolites of L-DOPA in mice brains.J Immunoassay Immunochem. 2004;25(4):359-70.

Lipton ML, Fu KM,. Branch CA, Schroeder CE: Bilateral Hand Representation in Primary Somatosensory Cortex., J Neuroscience, 26(1):180-185, 2006.

Michael L. Lipton, MD, PhD, Edwin Gulko, BA, Molly E. Zimmerman, PhD, Benjamin W. Friedman, MD, Mimi Kim, ScD, Erik Gellella, MD, Tamar Gold, BA, Keivan Shifteh, MD, Babak A. Ardekani, PhD, and Craig A. Branch, PhD:  Diffusion-Tensor Imaging Implicates Prefrontal Axonal Injury in Executive Function Impairment Following Very Mild Traumatic Brain Injury.  Radiology. 2009 Sep;252(3):816-24. Epub 2009 Jun 30.

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