Selected Achievements

Garner, T.P., Amgalan, D., Reyna, D.E., Li, S., Kitsis, R.N., and Gavathiotis, E. Small-molecule allosteric inhibitors of BAX. Nat Chem Biol (2019/Feb 4). PMID: 30718816.

Herrera, D.A., Kornblum, N., Acuna-Villaorduna, A., Sica, R.A., Shah, U., Butler, M., Vishnuvardhan, N., Shah, N., Bachier-Rodriguez, L., Derman, O., Shastri, A., Mantzaris, I., Verma, A.K., Braunchweig, I., and Janakiram, M. Barriers to Allogeneic Hematopoietic Stem Cell Transplant for Human T-Cell Lymphotropic Virus 1 associated Adult T-Cell Lymphoma-Leukemia in the United States: Experience from a large cohort in a major tertiary center. Biol Blood Marrow Transplant (2019/Feb 12). PMID: 30769194.

Li, Y., Zhang, D., Xu, L., Dong, L., Zheng, J., Lin, Y., Huang, J., Zhang, Y., Tao, Y., Zang, X., Li, D., and Du, M. Cell-cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models. Cell Mol Immunol (2019/Feb 18). PMID: 30778166.

Bresler, A., Mehta, V., Schiff, B.A., Smith, R.V., Khader, S., Ramos-Rivera, G., Lin, J., Libutti, S.K., Laird, A.M., and Ow, T.J. Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups. Head Neck (2019/Feb 21). PMID: 30793405.

Sparano, J.A. Techniques and Thresholds for Quantifying Circulating Tumor Cells in Breast Cancer-In Reply. JAMA oncology (2019/Feb 21). PMID: 30789630.

Ow, T.J., Fulcher, C.D., Thomas, C., Broin, P.O., Lopez, A., Reyna, D.E., Smith, R.V., Sarta, C., Prystowsky, M.B., Schlecht, N.F., Schiff, B.A., Rosenblatt, G., Belbin, T.J., Harris, T.M., Childs, G.C., Kawachi, N., Guha, C., and Gavathiotis, E. Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1. Oncotarget 104, 494-510 (2019/Jan 11). PMID: 30728900. PMCID: PMC6355180.

Ng, S.L., Leno-Duran, E., Samanta, D., Almo, S.C., and Strominger, J.L. Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells. Proc Natl Acad Sci U S A (2019/Jan 25). PMID: 30683721.

Anayannis, N.V., Schlecht, N.F., Ben-Dayan, M., Smith, R.V., Belbin, T.J., Ow, T.J., Blakaj, D.M., Burk, R.D., Leonard, S.M., Woodman, C.B., Parish, J.L., and Prystowsky, M.B. Association of an intact E2 gene with higher HPV viral load, higher viral oncogene expression, and improved clinical outcome in HPV16 positive head and neck squamous cell carcinoma. PLoS One 132, e0191581 (2018/. PMID: 29451891. PMCID: PMC5815588.

Carvajal, L.A., Neriah, D.B., Senecal, A., Benard, L., Thiruthuvanathan, V., Yatsenko, T., Narayanagari, S.R., Wheat, J.C., Todorova, T.I., Mitchell, K., et al. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med 10436, (2018/Apr 11). PMID: 29643228.

Riascos-Bernal, D.F., Sibinga, N.E.S., and Kitsis, R.N. PDCD5 says no to NO. Proc Natl Acad Sci U S A (2018/Apr 16). PMID: 29666279.

Chorro, L., Suzuki, M., Chin, S.S., Williams, T.M., Snapp, E.L., Odagiu, L., Labrecque, N., and Lauvau, G. Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape. Nature communications 91, 5368 (2018/Dec 18). PMID: 30560927. PMCID: PMC6299086.

Aluri, S., Zhao, R., Lubout, C., Goorden, S.M.I., Fiser, A., and Goldman, I.D. Hereditary folate malabsorption due to a mutation in the external gate of the proton-coupled folate transporter SLC46A1. Blood advances 21, 61-68 (2018/Jan 9). PMID: 29344585. PMCID: PMC5761628.

Cheng, H., Borczuk, A., Janakiram, M., Ren, X., Lin, J., Assal, A., Halmos, B., Perez-Soler, R., and Zang, X. Wide expression and significance of alternative immune checkpoint molecules, B7x and HHLA2, in PD-L1 negative human lung cancers. Clin Cancer Res (2018/Jan 26). PMID: 29374053.

Gizzi, A.S., Grove, T.L., Arnold, J.J., Jose, J., Jangra, R.K., Garforth, S.J., Du, Q., Cahill, S.M., Dulyaninova, N.G., Love, J.D., Chandran, K., Bresnick, A.R., Cameron, C.E., and Almo, S.C. Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome. Nature (2018/Jul 6). PMID: 29980769.

Miller, K.D., O'Neill, A., Gradishar, W., Hobday, T.J., Goldstein, L.J., Mayer, I.A., Bloom, S., Brufsky, A.M., Tevaarwerk, A.J., Sparano, J.A., Le-Lindqwister, N.A., Hendricks, C.B., Northfelt, D.W., Dang, C.T., and Sledge, G.W., Jr. Double-Blind Phase III Trial of Adjuvant Chemotherapy With and Without Bevacizumab in Patients With Lymph Node-Positive and High-Risk Lymph Node-Negative Breast Cancer (E5103). J Clin OncolJCO2018792028 (2018/Jul 24). PMID: 30040523.

Trujillo-Ocampo, A., Cho, H.-W., Herrmann, A.C., Ruiz-Vazquez, W., Thornton, A.B., He, H., Li, D.A.N., Qazilbash, M.A., Ma, Q., Porcelli, S.A., Shpall, E.J., Molldrem, J., and Im, J.S. Rapid ex vivo expansion of highly enriched human invariant natural killer T cells via single antigenic stimulation for cell therapy to prevent graft-versus-host disease. Cytotherapy (2018/Jul 31). PMID: 30076070.

Sparano, J.A., Gray, R.J., Makower, D.F., Pritchard, K.I., Albain, K.S., Hayes, D.F., Geyer, C.E., Jr., Dees, E.C., Goetz, M.P., Olson, J.A., Jr., et al. Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer. N Engl J Med (2018/Jun 3). PMID: 29860917.

Su, C.T., Bhargava, A., Shah, C.D., Halmos, B., Gucalp, R.A., Packer, S.H., Ohri, N., Haramati, L.B., Perez-Soler, R., and Cheng, H. Screening Patterns and Mortality Differences in Patients With Lung Cancer at an Urban Underserved Community. Clin Lung Cancer (2018/Jun 5). PMID: 29937386.

Yang, C.H., Wang, C., Ojima, I., and Horwitz, S.B. Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of beta-Tubulin and the Multidrug Resistance Associated P-Glycoprotein. J Nat Prod (2018/Mar 8). PMID: 29517223.

Chennamadhavuni, D., Saavedra-Avila, N.A., Carreno, L.J., Guberman-Pfeffer, M.J., Arora, P., Yongqing, T., Koay, H.F., Godfrey, D.I., Keshipeddy, S., Richardson, S.K., Sundararaj, S., Lo, J.H., Wen, X., Gascon, J.A., Yuan, W., Rossjohn, J., Le Nours, J., Porcelli, S.A., and Howell, A.R. Dual Modifications of alpha-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity. Cell chemical biology (2018/Mar 9). PMID: 29576533.

Ingram, J.R., Blomberg, O.S., Rashidian, M., Ali, L., Garforth, S., Fedorov, E., Fedorov, A.A., Bonanno, J.B., Le Gall, C., Crowley, S., Espinosa, C., Biary, T., Keliher, E.J., Weissleder, R., Almo, S.C., Dougan, S.K., Ploegh, H.L., and Dougan, M. Anti-CTLA-4 therapy requires an Fc domain for efficacy. Proc Natl Acad Sci U S A (2018/Mar 26). PMID: 29581255.

Ratner, L., Waldmann, T.A., Janakiram, M., and Brammer, J.E. Rapid Progression of Adult T-Cell Leukemia-Lymphoma after PD-1 Inhibitor Therapy. N Engl J Med 37820, 1947-1948 (2018/May 17). PMID: 29768155.

Zhou, S., Gravekamp, C., Bermudes, D., and Liu, K. Tumour-targeting bacteria engineered to fight cancer. Nat Rev Cancer (2018/Nov 7). PMID: 30405213.

Locke, F.L., Ghobadi, A., Jacobson, C.A., Miklos, D.B., Lekakis, L.J., Oluwole, O.O., Lin, Y., Braunschweig, I., Hill, B.T., Timmerman, J.M., et al. Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial. Lancet Oncol (2018/Nov 30). PMID: 30518502.

Sparano, J.A., and Henry, N.L. Surveillance After Treatment of Localized Breast Cancer: Time for Reappraisal? J Natl Cancer Inst (2018/Oct 11). PMID: 30312420.

Kao, Y.R., Chen, J., Narayanagari, S.R., Todorova, T.I., Aivalioti, M.M., Ferreira, M., Ramos, P.M., Pallaud, C., Mantzaris, I., Shastri, A., Bussel, J.B., Verma, A., Steidl, U., and Will, B. Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag. Sci Transl Med 10458, (2018/Sep 12). PMID: 30209246.

Jayasekera, J., Schechter, C.B., Sparano, J.A., Jagsi, R., White, J., Chapman, J.W., Whelan, T., Anderson, S.J., Fyles, A.W., Sauerbrei, W., et al. Effects of Radiotherapy in Early-Stage, Low-Recurrence Risk, Hormone-Sensitive Breast Cancer. J Natl Cancer Inst (2018/Sep 18). PMID: 30239794.

Paz-Ares, L., Luft, A., Vicente, D., Tafreshi, A., Gumus, M., Mazieres, J., Hermes, B., Cay Senler, F., Csoszi, T., Fulop, A., et al. Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer. N Engl J Med (2018/Sep 25). PMID: 30280635.