Selected Achievements

Guan, F., Tabrizian, T., Novaj, A., Nakanishi, M., Rosenberg, D.W., and Huffman, D.M. Dietary Walnuts Protect Against Obesity-Driven Intestinal Stem Cell Decline and Tumorigenesis. Frontiers in nutrition 537 (2018/. PMID: 29904634. PMCID: PMC5990619.

Wang, Z., Zolnik, C.P., Qiu, Y., Usyk, M., Wang, T., Strickler, H.D., Isasi, C.R., Kaplan, R.C., Kurland, I.J., Qi, Q., and Burk, R.D. Comparison of Fecal Collection Methods for Microbiome and Metabolomics Studies. Frontiers in cellular and infection microbiology 8301 (2018/. PMID: 30234027. PMCID: PMC6127643. 

Schneider, M., Kumar, V., Nordstrom, L.U., Feng, L., Takeuchi, H., Hao, H., Luca, V.C., Garcia, K.C., Stanley, P., Wu, P., and Haltiwanger, R.S. Inhibition of Delta-induced Notch signaling using fucose analogs. Nat Chem Biol 141, 65-71 (2018/Jan). PMID: 29176671. PMCID: PMC5726916.

Hodge, D.Q., Cui, J., Gamble, M.J., and Guo, W. Histone Variant MacroH2A1 Plays an Isoform-Specific Role in Suppressing Epithelial-Mesenchymal Transition. Sci Rep 81, 841 (2018/Jan 16). PMID: 29339820.

Kauffman, K.M., Hussain, F.A., Yang, J., Arevalo, P., Brown, J.M., Chang, W.K., VanInsberghe, D., Elsherbini, J., Sharma, R.S., Cutler, M.B., Kelly, L., and Polz, M.F. A major lineage of non-tailed dsDNA viruses as unrecognized killers of marine bacteria. Nature 5547690, 118-122 (2018/Jan 24). PMID: 29364876  

Choi, J., Rakhilin, N., Gadamsetty, P., Joe, D.J., Tabrizian, T., Lipkin, S.M., Huffman, D.M., Shen, X., and Nishimura, N. Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging. Sci Rep 81, 10989 (2018/Jul 20). PMID: 30030455.

Ruiz, P.D., and Gamble, M.J. MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20. Nature communications 91, 5143 (2018/Dec 3).  PMID: 30510186. PMCID: PMC6277393.

Mao, K., Quipildor, G.F., Tabrizian, T., Novaj, A., Guan, F., Walters, R.O., Delahaye, F., Hubbard, G.B., Ikeno, Y., Ejima, K., Li, P., Allison, D.B., Salimi-Moosavi, H., Beltran, P.J., Cohen, P., Barzilai, N., and Huffman, D.M. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nature communications 91, 2394 (2018/Jun 19). PMID: 29921922. PMCID: PMC6008442.

Bejarano, E., Murray, J.W., Wang, X., Pampliega, O., Yin, D., Patel, B., Yuste, A., Wolkoff, A.W., and Cuervo, A.M. Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging. Aging cell e12777 (2018/May 29). PMID: 29845728.

Hayakawa, Y., Tsuboi, M., Asfaha, S., Kinoshita, H., Niikura, R., Konishi, M., Hata, M., Oya, Y., Kim, W., Middelhoff, M., et al. BHLHA15-positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice. Gastroenterology (2018/Nov 15). PMID: 30448068.

Zhang, L., and Vijg, J. Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging. Annu Rev Genet (2018/Sep 13). PMID: 30212236.

Barzilai, N., Cuervo, A.M., and Austad, S. Aging as a Biological Target for Prevention and Therapy. JAMA (2018/Sep 17). PMID: 30242337.

Guthrie, L., Gupta, S., Daily, J., and Kelly, L. Human microbiome signatures of differential colorectal cancer drug metabolism. NPJ biofilms and microbiomes 327 (2017/. PMID: 29104759. PMCID: PMC5665930.

Tadesse, S., Corner, G., Dhima, E., Houston, M., Guha, C., Augenlicht, L., and Velcich, A. MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa. Oncotarget 842, 71456-71470 (2017/Apr 06). PMID: 28431399. PMCID: PMC5641062  

Tabrizian, T., Wang, D., Guan, F., Hu, Z., Beck, A.P., Delahaye, F., and Huffman, D.M. Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis. Endocr Relat Cancer 246, 253-265 (2017/Jun). PMID: 28351943. PMCID: PMC5505256.         

Esteban-Martinez, L., Sierra-Filardi, E., McGreal, R.S., Salazar-Roa, M., Marino, G., Seco, E., Durand, S., Enot, D., Grana, O., Malumbres, M., Cvekl, A., Cuervo, A.M., Kroemer, G., and Boya, P. Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J 3612, 1688-1706 (2017/Jun 14). PMID: 28465321. PMCID: PMC5470043.

Augenlicht, L.H. Environmental Impact on Intestinal Stem Cell Functions in Mucosal Homeostasis and Tumorigenesis. J Cell Biochem 1185, 943-952 (2017/May). PMID: 27584938.    

Dong, X., Zhang, L., Milholland, B., Lee, M., Maslov, A.Y., Wang, T., and Vijg, J. Accurate identification of single-nucleotide variants in whole-genome-amplified single cells. Nat Methods 145, 491-493 (2017/May). PMID: 28319112. PMCID: PMC5408311.

Luo, X., Yu, Z., Deng, C., Zhang, J., Ren, G., Sun, A., Mani, S., Wang, Z., and Dou, W. Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice. Sci Rep 71, 16374 (2017/Nov 27). PMID: 29180692. PMCID: PMC5703971. 

Downs, I.A., Aroniadis, O.C., Kelly, L., and Brandt, L.J. Postinfection Irritable Bowel Syndrome: The Links Between Gastroenteritis, Inflammation, the Microbiome, and Functional Disease. J Clin Gastroenterol 5110, 869-877 (2017/Nov/Dec). PMID: 28885302.

Jahid, S., Sun, J., Gelincik, O., Blecua, P., Edelmann, W., Kucherlapati, R., Zhou, K., Jasin, M., Gumus, Z.H., and Lipkin, S.M. Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair. Oncotarget 842, 71574-71586 (2017/Sep 22). PMID: 29069730. PMCID: PMC5641073.

Lee, K., Tosti, E., and Edelmann, W. Mouse models of DNA mismatch repair in cancer research. DNA Repair (Amst) 38140-146 (2016/Feb). PMID: 26708047. PMCID: PMC4754788.

Borras, E., San Lucas, F.A., Chang, K., Zhou, R., Masand, G., Fowler, J., Mork, M.E., You, Y.N., Taggart, M.W., McAllister, F., Jones, D.A., Davies, G.E., Edelmann, W., Ehli, E.A., Lynch, P.M., Hawk, E.T., Capella, G., Scheet, P., and Vilar, E. Genomic Landscape of Colorectal Mucosa and Adenomas. Cancer Prev Res (Phila) 96, 417-427 (2016/Jun). PMID: 27221540. PMCID: PMC4941624.  

Srinivasan, T.,Than, E. B., Bu, P.,Tung, K. L., Chen, K. Y., Augenlicht, L., Lipkin, S. M., Shen, X. Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells. Sci Rep 6, 26069, (2016). PMID: 27181744. PMCID: PMC4867651 

Srinivasan, T., Walters, J., Bu, P., Than, E.B., Tung, K.L., Chen, K.Y., Panarelli, N., Milsom, J., Augenlicht, L., Lipkin, S.M., and Shen, X. NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells. Cancer Res 7611, 3411-3421 (2016/Jun 01). PMID: 27197180. PMCID: PMC4891252.

Protiva, P., Pendyala, S., Nelson, C., Augenlicht, L.H., Lipkin, M., and Holt, P.R. Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial. Am J Clin Nutr 1035, 1224-1231 (2016/May). PMID: 27009752. PMCID: PMC4841933.  

Saha, S., Aranda, E., Hayakawa, Y., Bhanja, P., Atay, S., Brodin, N.P., Li, J., Asfaha, S., Liu, L., Tailor, Y., Zhang, J., Godwin, A.K., Tome, W.A., Wang, T.C., Guha, C., and Pollard, J.W. Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury. Nature communications 713096 (2016/Oct 13). PMID: 27734833. PMCID: PMC5065628.           

Vermeij, W.P., Dolle, M.E., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C.R., Wu, H., Roks, A.J., Botter, S.M., van der Eerden, B.C., Youssef, S.A., Kuiper, R.V., Nagarajah, B., van Oostrom, C.T., Brandt, R.M., Barnhoorn, S., Imholz, S., Pennings, J.L., de Bruin, A., Gyenis, A., Pothof, J., Vijg, J., van Steeg, H., and Hoeijmakers, J.H. Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature 5377620, 427-431 (2016/Sep 15). PMID: 27556946. PMCID: PMC5161687.

 Brave, M., Lukin, D.J., and Mani, S. Microbial control of intestinal innate immunity. Oncotarget 624, 19962-19963 (2015/Aug 21). PMID: 26172839. PMCID: PMC4652977

Peregrina, K., Houston, M., Daroqui, C., Dhima, E., Sellers, R.S., and Augenlicht, L.H. Vitamin D is a determinant of mouse intestinal Lgr5 stem cell functions. Carcinogenesis 361, 25-31 (2015/Jan). PMID: 25344836. PMCID: PMC4303796.  

Chen, H.J., Sun, J., Huang, Z., Hou, H., Jr., Arcilla, M., Rakhilin, N., Joe, D.J., Choi, J., Gadamsetty, P., Milsom, J., Nandakumar, G., Longman, R., Zhou, X.K., Edwards, R., Chen, J., Chen, K.Y., Bu, P., Wang, L., Xu, Y., Munroe, R., Abratte, C., Miller, A.D., Gumus, Z.H., Shuler, M., Nishimura, N., Edelmann, W., Shen, X., and Lipkin, S.M. Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. Nat Biotechnol 336, 656-660 (2015/Jun). PMID: 26006007. PMCID: PMC4532544. 

Asfaha, S., Hayakawa, Y., Muley, A., Stokes, S., Graham, T.A., Ericksen, R.E., Westphalen, C.B., von Burstin, J., Mastracci, T.L., Worthley, D.L., Guha, C., Quante, M., Rustgi, A.K., and Wang, T.C. Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine. Cell stem cell 166, 627-638 (2015/Jun 04). PMID: 26046762. PMCID: PMC4457942.          

Wallace, B.D., Roberts, A.B., Pollet, R.M., Ingle, J.D., Biernat, K.A., Pellock, S.J., Venkatesh, M.K., Guthrie, L., O'Neal, S.K., Robinson, S.J., Dollinger, M., Figueroa, E., McShane, S.R., Cohen, R.D., Jin, J., Frye, S.V., Zamboni, W.C., Pepe-Ranney, C., Mani, S., Kelly, L., and Redinbo, M.R. Structure and Inhibition of Microbiome beta-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chem Biol 229, 1238-1249 (2015/Sep 17. ). PMID: 26364932. PMCID: PMC4575908. 

Augenlicht, L. Hidden effects of mouse chow. Science 346, 6210 (2014). PMID: 25278593 

Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., Comerma, L., Huang, B., Blander, J. M., Xiong, H., Mayer, L., Berin, C., Augenlicht, L. H., Velcich, A., Cerutti, A. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342, 447-453 (2013). PMID: 24072822. PMCID: PMC4005805