Harry Eagle Postdoctoral Scholar Dr. Harry Eagle was the founding Chair of the Department of Cell Biology and the first Director of the Albert Einstein Cancer Center. He was a hugely influential and visionary leader in the early years of our medical school. As a medical scientist, Dr. Eagle published prolifically and made many important discoveries in medicine. His best-known achievement was his formulation of the Eagle’s medium in 1959, which ushered in the era of animal cell culture and in vitro cell studies in modern medicine. By naming the department’s most distinguished Postdoctoral Scholarship after Dr. Eagle, we seek to identify exceptional young researchers who have shown clear evidence of scientific productivity and excellence and would like to further develop their career by joining our highly dynamic and stimulating research community. Our goal is to inspire and cultivate tomorrow’s science innovators and leaders who will follow in the footsteps of Dr. Eagle and pioneer new science. Stipend $75,000/year Applicants should be within 2 years of the completion of their PhD or MD-PhD degree and have a proven track record of excellence in research. The Department of Cell Biology and the Albert Einstein College of Medicine offer outstanding state-of-the-art facilities to conduct molecular and cellular biology studies. The College offers subsidized housing. The award is for two years with eligibility for a third year. The following faculty are part of the program: Julio Aguirre-Ghiso Cancer Dormancy: understanding the biology of Metastasis Leonard Augenlicht Nutritional and genetic regulation of intestinal homeostasis and stem cell functions. Eric Bouhassira Stem cell biology, epigenetics, erythropoiesis, DNA replication. Robert Coleman Human tumorigenesis is a complicated process marked by a loss of the cell’s ability to regulate critical cellular processes, such as transcription, RNA processing and translation, leading to uncontrollable cell growth. John Codeelis Interests are in optical physics, cell biology and biophysics, cancer biology and mouse models of cancer. Development of the multiphoton imaging technology used to identify intravasation microenvironments in metastatic tumors. Winfried Edelmann Mouse models to study DNA repair genes in cancer and meiosis. Dmitry Fyodorov Chromosome assembly and dynamics; ATP-dependent nucleosome remodeling; histone chaperones; sperm chromatin; Drosophila melanogaster. Matthew Gamble Regulation of chromatin structure and function during cancer and senescence by the histone variant macroH2A. Kira Gritsman The P13 Kinase signaling pathway in adult blood development and leukemia. Wenjun Guo Regulation of stem-cell states in the mammary gland and breast cancer. Keisuke Ito Biomedical research aiming toward the development of stem cell therapies. Margaret Kielian Virus assembly and budding; host factors in virus infection; virus-membrane fusion. Richard Kitsis Fundamental mechanisms of cell death and their application to heart disease and cancer. Lindsay LaFave Our lab uses state-of-the art epigenomic approaches to examine gene regulatory programs that drive cellular diversity in lung cancer progression. Thomas Meier Our group is studying the mechanism and regulation of nucleolar ribonucleoprotein biogenesis in relation to genetic disease, cancer, and human reproduction. Maria Marianovich Hematopoietic stem cell and cancer stem cell microenvironment. Our lab studies mechanisms that regulate the maintenance of bone marrow niches for hematopoietic stem cells during homeostasis, aging, or myeloid malignancy. Satish Nandakumar Genetics of Blood Cancer Predisposition. Charles Query Mechanism and modulation of spliceosome function. Rebeca San Martin Prostate cancer microenvironment. Bone metastasis and dormancy. Development of alternative in-vitro systems that model progression and metastasis. Matthew Scharff Molecular basis of mutation and switching of immunoglobulin genes and use of monoclonal antibodies in infections. Carl Schildkraut Role of dynamic DNA structures in the etiology of cancer, fragile X syndrome and telomere dysfunction. Projects include studies in embryonic stem cells. Robert Singer RNA trafficking Arthur Skoultchi Chromatin structure and function; normal and malignant hematopoiesis; cell cycle regulation; embryonic stem cells and knock-out mice. Pamela Stanley Functions of mammalian glycans in development, spermatogenesis and Notch signaling. Ulrich Steidl Transcriptional dysregulation of pre-leukemic cell states and their therapeutic targeting. Britta Will Mechanisms of stem cell aging and transformation. Kristy Stengel Deregulated gene expression is a hallmark of cancer. Our goal is to understand how recurrent alterations in transcription factor proteins (e.g. mutation, translocation) disrupt normal gene expression networks to trigger cancer development. B. Hilda Ye Oncogenes in the development of normal and malignant B cells. Interested individuals should contact one of the above faculty members at Department of Cell Biology, Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, New York, NY 10461. Applications should consist of a CV and three letters of recommendation and are evaluated throughout the year.