Peng Wu, Ph.D.
Associate Professor, Department of Biochemistry
Dr. Wu's research integrates synthetic chemistry with biochemistry to explore the
relevance of glycosylation in human disease. The glycome, defined as the full
complement of glycans that a cell produces, is involved in a variety of physiological
processes, including angiogenesis, fertilization, stem cell development and neuronal
development. Changes in the glycome have also been shown to mark the onset of cancer
and inflammation. The wealth of biological information encoded in the glycome has
motivated Wu lab researchers to develop methods for its retrieval. full bio>>
Key Publications
- Soriano Del Amo, D.; Wang, W.; Jiang, H.; Besanceney C.; Yan A.C.; Levy, M.; Liu, Y.; Marlow, F.L.; Wu, P. Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans. J. Am. Chem. Soc. 2010, 132, 16893.
- Feng, L.; Jiang, H.; Wu, P., Marlow, F.L. Negative Feedback Regulation of Wnt Signaling via N-linked Fucosylation in Zebrafish. Dev. Biol. 2014, 395, 268.
- Nordstrøm, L.; Sironi, J.; Aranda, E.; Maisonet, J.; Perez-Soler, R.; Wu, P.; Schwartz, E. Discovery of Autophagy Inhibitors with Anti-proliferative Activity in Lung and Pancreatic Cancer Cells. ACS. Med. Chem. Lett. 2015.
- Wang, W.; Hu, T.; Frantom, P. A.; Zheng, T; Gerwe, B.; Soriano del Amo, D.; Seidel, R.D. III, Wu, P. Chemoenzymatic Synthesis of GDP-L-fucose and the Lewis X Glycan Derivatives. Proc. Natl. Acad. Sci. USA. 2009, 106, 16096.
- Zheng, T.; Jiang, H.; Gros, M., Soriano del Amo, D.; Sundaram, S.; Lauvau, G.; Marlow, F.; Liu, Y., Stanley, P.; Wu, P. Tracking N-acetyllactosamine on Cell Surface Glycans in Vivo. Angew. Chem. Int. Ed. 2011, 50, 4113.