Nicholas E. S. Sibinga, M.D.

Nicholas E. S. Sibinga, M.D.
Associate Professor, Departments of Medicine (Cardiology) and of Developmental & Molecular Biology  

Dr. Sibinga and colleagues focus on restenosis, the re-narrowing of arteries—which often occurs after arteries have been widened by balloon angioplasty. They have identified new proteins activated after vascular injury, and their findings suggest that these proteins or protein fragments may be useful as therapies for controlling inflam­mation and other activities that occur within the walls of blood vessels. They will soon be testing these proteins in animals, with the goal of developing new ways to prevent restenosis, heart attacks, and strokes. full bio>> 

Key Publications

1. Hiroyasu S, Chinnasamy P, Hou R, Hotchkiss K, Casimiro I, Dai XM, Stanley ER, Sibinga NES. Donor and recipient cell surface colony stimulating factor-1 promote neointimal formation in transplant-associated arteriosclerosis. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):87-95.
2. Casimiro I, Chinnasamy P, Sibinga NES. Genetic inactivation of the allograft inflammatory factor-1 locus. Genesis, the Journal of Genetics and Development. 2013 Aug 8:1-7.
3. Bruder-Nascimento T, Chinnasamy P,,Riascos-Bernal DF, Cau SB, Callera GE, Touyz RM, Tostes RC, Sibinga NES. Angiotensin II induces Fat1 expression/activation and vascular smooth muscle cell migration via Nox1-dependent reactive oxygen species generation. J Mol Cell Cardiol, 2014 Jan 66:18-26.
4. Chinnasamy P, Lutz S, Casimiro I, Brosnan C, Sibinga, NES. Loss of Allograft inflammatory factor-1 ameliorates experimental autoimmune encephalomyelitis by limiting encephalitogenic CD4 T cell expansion. Molecular Medicine, 2015 Jan 6.
5. Riascos-Bernal D, Chinnasamy P, Valenta T, Basler K, Sibinga, NES. Beta-catenin C-terminal signaling suppresses p53 and is essential for arterial wall formation. In revision.

Funding

1. 2015/03/16-2019/02/28
   R01 HL128066-01, National Heart, Lung and Blood Institute (NHLBI)
   Sibinga, Nicholas E
   Allograft inflammatory factor-1 in atherosclerosis
   Role: PI
2. 2013/07/01-2016/06/30
   13GRNT16950064, American Heart Association
   Sibinga, Nicholas E
   Beta-catenin in vascular remodeling and disease
   This proposal addresses the role of beta-catenin structural and signaling functions in vascular development and adult vascular response to injury.
   Role: PI