Kelvin Davies, Ph.D.
Professor, Department of Urology
Professor, Department of Physiology & Biophysics
Dr. Davies's research applies biochemical and molecular mechanisms to understand
urogenital pathology, particularly the role of smooth muscle in the development of
urogenital pathology. The primary goal of these basic science studies is clinical
translation and Dr. Davies’s work has resulted in the first and only FDA-approved
clinical trials of gene therapy to treat benign urologic disease (over-active bladder
and erectile dysfunction (ED)). full bio>>
Key Publications
- Calenda, G., Tong, Y., Kanika, N.D., Tar, M.T., Suadicani, S.O., Xhang, X., Melman, A,, Rougeot, C., Davies, K.P. (2011) Reversal of Diabetic Vasculopathy in a Rat Model of Type 1 Diabetes by Opiorphin-Related Peptides. Am J Physiol Heart Circ Physiol. 301(4):H1353-9.
- Calenda, G., Suadicani, S., Iglesias, R., Spray, D., Melman, A., and Davies, K.P. (2011) Silencing MaxiK activity in corporal smooth muscle cells initiates compensatory mechanisms to maintain calcium homeostasis. J. Sex Med. Aug;8(8):2191-204.
- Wang, Y., Tar, M.T., Wang, H.Z., Fu, S., Melman, A. and Davies, K.P. (2014) Diabetes induced changes in tension and phasic contractions of isolated bladder strips correlate with modulated Kv7 channel activity. International Journal of Urology, 21(10):1059-64.
- Tar, M.T., Cabrales, P., Mahantesh, N., Nacharaju, P., Friedman, A., Friedman, J. and Davies, K.P. (2014) Nanoparticles encapsulating NO can increase intracorporal pressure and elicit spontaneous erections in a rat model of radical prostatectomy. J Sex Med. 11(12):2903-14.
- Fu, S. Tar, M.T., Melman, A. and Davies, K.P. (2014) Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells. FASEB Journal, 28(8):3633-44.