Jorge Kizer, M.D.

Jorge Kizer, M.D.
Associate Professor, Department of Medicine (Cardiology)
Associate Professor, Department of Epidemiology & Population Health
Director of Clinical Cardiovascular Research, Department of Medicine 

Dr. Jorge Kizer's research focuses on advancing understanding of biochemical and imaging determinants of cardiovascular disease and stroke, with the goal of improving diagnosis and treatment of these disorders. His key areas of interest are obesity and the aging process, and how bioactive factors secreted by adipocytes, skeletal myocytes, and cardiomyocytes, among other cell types, lead to dysregulation of homeostatic mechanisms and promote the development of metabolic and cardiovascular diseases. A related area of investigation is HIV infection, and the roles of chronic immune activation and inflammation, and associated perturbations in metaboiism and adipose tissue distribution, in accelerated heart and vascular dysfunction. full bio>> 

Key Publications

1. Kizer JR, Arnold AM, Strotmeyer ES, Ives DG, Cushman M, Ding J, Kritchevsky SB, Chaves PHM, Hirsch CH, Newman AB. Change in Circulating Adiponectin in Advanced Old Age: Determinants and Impact on Physical Function and Mortality. The Cardiovascular Health Study All Stars Study. J Gerontol A Biol Sci Med Sci 2010;65:1208-1214.
2. Kizer JR, Arnold AM, Benkeser D, Ix JH, Djoussé L, Zieman SJ, Barzilay JI, Tracy RP, Mantzoros CS, Siscovick DS, Mukamal KJ. Total and High-Molecular-Weight Adiponectin and Risk of Incident Diabetes in Older People. Diabetes Care 2012;35:415-423.
3. Kizer JR, Umans JG, Zhu J, Devereux RB, Wolfert RL, Lee ET, Howard BV. Lipoprotein-Associated Phospholipase A2 Mass and Activity and Risk of Cardiovascular Disease in a Population with High Prevalences of Obesity and Diabetes: The Strong Heart Study. Diabetes Care 2012;35:840-847.
4. Kizer JR, Benkeser D, Arnold AM, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Tracy RP, Mantzoros CS, deFilippi CR, Newman AB, Djoussé L. Associations of Total and High-Molecular-Weight Adiponectin with All-cause and Cardiovascular Mortality in Older Persons: The Cardiovascular Health Study. Circulation 2012;126:2951-2961.
5. Macheret F, Bartz TM, Djoussé L, Ix JH, Mukamal KJ, Zieman SJ, Siscovick DS, Tracy RP, Heckbert SR, Psaty BM, Kizer JR. Higher Circulating Adiponectin Levels are Associated with Increased Risk of Atrial Fibrillation in Older Adults. Heart.

Funding

1. PCORI
   Califf (PI)
   9/1/15-8/31/18
   Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness (ADAPTABLE).
   Randomized trial whose aim is to compare the effectiveness of standard-dose versus low-dose aspirin in secondary prevention of cardiovascular disease using the PCORNet structure, including Clinical Data Research Networks (CDRNs).
   Role: Cardiology PI, New York City CDRN
2. R01 HL094555
   Kizer (MPI)
   9/1/09-6/30/15
   NIH/NHLBI
   Determinants and Cardiovascular Consequences of Diabetes in Older Adults
   Objective is to evaluate adipocyte- and hepatocyte-derived biomarkers, as well as advanced glycation endproducts and fibrotic pathways, in the pathogenesis of diabetes and its cardiovascular complications.
   Role: MPI
3. R01 HL107899
   Lee (PI)
   5/1/11-4/30/16
   NIH/NHLBI
   Androgen-Estrogen Balance in Cardiovascular Disease Risk
   Aims are to determine the associations of circulating androgen and estrogen concentrations, and their longitudinal change, on subclinical and clinical cardiovascular disease in American Indians.
   Role: Co-I
4. R01 AG023629
   Newman (PI)
   9/1/11-5/31/16
   NIH/NIA
   Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)
   Objectives are to evaluate the impact of changes in inflammatory, hormonal and metabolic biomarkers on aging-associated disease processes and functional decline, and conversely, to identify a clinical and biochemical profile predictive of exceptional survival.
   Role: Co-I
5. HHSN268201300002
   Kaplan (PI)
   6/1/13-9/30/18
   Study of Latinos Field Center
   Objective is to serve as a field center for recruitment and evaluation of returning participants for the next phase of the Hispanic Community Health Study/Study of Latinos.
   Role: Co-I